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GLP-1 receptor agonist medications such as semaglutide are designed to resist rapid breakdown in the body, allowing for sustained activity

This allele has been associated with DNA methylation 35 , which might be down-regulating the GSTP1 gene expression 36

Why Deficiency Matters Even mild deficiency can cause wide-ranging symptoms: Persistent fatigue or low energy Brain fog, mood changes, or poor concentration Tingling or numbness in hands and feet Pale skin or shortness of breath Reduced immune function These occur because B12 is critical for oxygen transport and nerve conduction

Each of these errors increases tissue trauma and reaction severity