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Once absorbed, intracellular esterases remove the acetyl group to release free glutathione
In diarrhea-predominant IBS (IBS-D), electron microscopy studies showed cytoskeleton condensation and enlarged intercellular spaces between epithelial cells, providing the morphological basis for increased intestinal permeability in IBS
Unlike native amylin, which is rapidly degraded, Cagrilintides structural modifications allow for once-weekly subcutaneous administration, improving clinical practicality and adherence
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