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Patients who skip the escalation or increase doses too quickly are significantly more likely to experience severe nausea, vomiting, and other gastrointestinal side effects that may lead them to discontinue treatment entirely

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Anyone who experiences rapid weight loss or fluid loss can end up with acute kidney injury (AKI), which can be extreme enough to require hospitalization and even dialysis to recover from, says Ramesh Khanna, MD, chair of nephrology at MU Health Care

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