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The weight loss mechanism differs as well: GLP-1 agonists work through delayed gastric emptying and central appetite suppression, while berberine's weight effects, when present, likely relate to improved insulin sensitivity and metabolic efficiency

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The Therapeutic Goods Administration (TGA) has already approved a higher dose of semaglutide, the active ingredient in Ozempic, to be sold as Wegovy in Australia for weight loss among those with a body mass index (BMI) over 30 but this is not yet available due to supply shortages