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Experimental models have demonstrated that interference with TF expression or activity reduces tumor outgrowth and metastatic potential, while clinically, overexpression of TF has been found to be associated with disease progression and poor prognosis in solid tumors 146,147
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Treatment duration proves critical variable where longer courses create more durable changes - users completing 2-3 month treatments typically maintain 20-40% of peak benefits long-term, 4-6 month treatments sustain 40-60% of improvements, and 6-12+ month courses preserve 50-70% of maximum benefits potentially indefinitely
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