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Type III and IV individuals demonstrate visible darkening within 1421 days but continue deepening through week 8
While purine nucleotide synthesis is selectively affected through Nrf2 activation, c-Myc is involved in the regulation of both purine and pyrimidine nucleotide synthesis
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elegans by regulating the mTOR signaling pathway and suppressing the release of CCL11 cytokines, which are connected to age-related cellular and tissue impairments (Thakkar et al., 2013
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