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Uremic toxins originating from colonic microbial metabolism
The disorder usually presents in early childhood and is characterized by episodes of hypoketotic hypoglycemia (that can cause encephalopathy), hepatomegaly, elevated liver enzymes (transaminases), and hypoammonemia in infants
Considering the above, future lines of research should focus on the proper dose, timing, safety and frequency when administering GLP-1 analogs and conjugated estradiol as a treatment for body weight disorders
Its also worth noting that an oral version of Wegovy may be available soon
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