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Most providers who support split dosing recommend starting with the simplest modification, twice weekly, before considering more frequent schedules

10.1002/iub.1466 73 XiaZ.MiaoJ.ChenB.GuoJ.OuY.LiangX.et al (2022)

The mechanisms behind this increased risk are multifactorial: Iron and Estrogen Synergy: In breast tissue, iron synergizes with estrogen metabolites to generate reactive species, a process intensified in post-menopause when iron stores rise