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A varied diet often provides enough carnitine for healthy adults
58 , 59 Furthermore, tirzepatide-induced decreases in adipocyte mass (and thus, cystatin C production) might cause artifactual increases in eGFR-cystatin C, potentially explaining why tirzepatide-related changes in eGFR-cystatin were consistently shifted toward more positive values (when compared with tirzepatide-related changes in eGFR-creatinine) at all time points following randomization (Figure 4)
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