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2 Materials and methods 2.1 Plasmid construction Constructs pGEX-6P-1- cntA and pACYCDuet-1- cntB (for the individual production of CntA and CntB) and also plasmid pGEX-6P-1- cntAB (for the co-production of CntA and CntB) were described recently ( A

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Body composition testing reveals that many of these patients are losing significant skeletal muscle mass, effectively depleting their metabolic engines despite reaching a "normal" BMI

3) and an improvement in quality of life.40 Pending the results of cardiovascular safety studies in obesity (SURMOUNT MMO) and diabetes (SURPASS-CVOT), TZP has demonstrated in the SURMOUNT-1 trial a reduction in the predicted 10-year cardiovascular risk in patients with obesity and an initially moderate-to-high risk of cardiovascular disease.43 TZP treatment effectively reduces the apnoeahypopnoea index by up to 23 events per hour, as well as blood pressure, C-reactive protein, and symptoms related to poor sleep quality (as assessed by PROMIS Sleep scales), likely due to weight loss and improvement in adipocyte dysfunction.44 Moreover, TZP induces remission of histologically confirmed metabolic dysfunction-associated steatohepatitis (MASH) in a dose-dependent manner (4462% of cases, depending on the dose) and leads to improvement of at least one stage of liver fibrosis in 5155% of caseshigher than that observed with placebo45 (Fig