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This means insulin release occurs only when blood glucose levels are elevated, reducing the risk of hypoglycemia compared to other antidiabetic agents, though this risk increases when used with insulin or sulfonylureas

Methods This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations.17 Inclusion criteria The protocol of this study was based on the Patients of interest, Intervention to be studied, Comparison of intervention, and Outcome of interest (PICO) methodology