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Studies have found that people with overweight or obesity may have a reduction in incretin effects, particularly if they have had frequent weight fluctuations due to yo-yo dieting
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However, during the writing of this article, we discovered the need for more research to understand the interplay between the nervous system and gastrointestinal hormones, unexplored GLP-1 or GIP receptors, genetic background, endocrine cells, and the composition of dietary intake
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