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Two patients paying identical monthly fees may experience vastly different value based on genetic predispositions, baseline metabolic state, and provider expertise in dose titration and adverse event management
However, a drawback of these medicines has been the necessity for administration by subcutaneous injection, which limits patient utilization and may reduce opportunities for fixed-dose combination treatments with other small-molecule drugs
Trovato et al 315 showed even more dramatic results in a placebo-controlled randomized study conducted before the availability of erythropoietin
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