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Adult Growth Hormone Insufficiency Research Age-Related Hormone Decline Studies Research in aging populations examined sermorelins ability to restore youthful growth hormone secretory patterns: Short-term administration reversed age-related declines in mean 24-hour growth hormone and IGF-1 levels in elderly men Nocturnal growth hormone secretion showed particular enhancement with bedtime dosing Studies in subjects aged 60-78 years demonstrated near-doubling of 12-hour mean growth hormone release IGF-1 responses varied, with some studies showing significant increases while others found modest changes A landmark 1992 study comparing young men aged 22-33 years with elderly men aged 60-78 years found that sermorelin successfully restored growth hormone and IGF-1 levels in older subjects to approximate those of younger men

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PMID: 22537212 | DOI: 10.1111/j.1753-4887.2012.00476.x [21] Machowetz A, Poulsen HE, Gruendel S, et al

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