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Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens

It is taken once daily on an empty stomach, 30 minutes before food, and requires specific administration to achieve therapeutic levelsa practical consideration for adherence and efficacy

For libido enhancement research, dosages of 1-2mg/daily are administered up to four times monthly, with a minimum 48-hour interval between the administrations [8, 13, 26]