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Key findings from our study: Tirzepatide 15 mg and CagriSema demonstrated the greatest overall weight reduction CagriSema showed the strongest performance at the 20% weight loss threshold Higher efficacy was generally accompanied by increased gastrointestinal adverse events Serious adverse events remained broadly comparable to placebo across regimens As obesity medicine rapidly evolves toward multi-pathway and combination therapies, comparative evidence like this becomes increasingly important for individualized treatment decisions and future guideline development

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For more information about Trulicity pen, see the How to Use page from the drug maker or talk to your health care provider.

In the context, Figure 2 shows that GLP-1RA-driven microbiota changes coordinate SCFA and bile acid signaling, promoting WAT beiging and gut-brain axis-mediated energy balance