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GLP-1 Drugs: What Employers Need to Know GLP-1 drugs like Ozempic and Zepbound have gained significant attention in recent years for treating both diabetes and assisting with weight loss
Once-weekly trelagliptin versus daily alogliptin in Japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study
In the UK, hydroxocobalamin 1 mg intramuscular injection is used: Without neurological involvement : 1 mg three times weekly for two weeks, then maintenance of 1 mg every two to three months With neurological involvement : 1 mg on alternate days until no further improvement in symptoms, then maintenance of 1 mg every two months [6] [7] Lifelong maintenance is required for pernicious anaemia or other irreversible causes of deficiency Oral B12 supplementation may be appropriate for diet-related deficiency in patients without neurological symptoms and with adequate absorption capacity
GLP-1 medications cause constipation by slowing gastric emptying and overall gut transit time Macrogol preparations retain water in stool and are recommended for long-term use with GLP-1 therapy Bulk-forming laxatives like ispaghula husk are first-line treatment according to NICE guidance Adequate hydration (1.52 litres daily) is essential when using laxatives with GLP-1 medications Patients should seek medical advice if constipation persists beyond 12 weeks despite treatment Table of Contents Have questions about Wegovy
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