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A randomized trial demonstrated that weekly oral vitamin D supplementation during neoadjuvant therapy significantly improved pathologic complete response rates in breast cancer patients, particularly those with hormone receptornegative tumors and high Ki67 expression
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However, other factors may be involved, including accumulation of lactate, pyruvate, glutamine and free glucose, and depletion of glycogen, ketone bodies and glutamate
In this context, PLGA nanocarriers have emerged as an effective platform for delivering pharmacological agents and natural compounds including essential oils 100 , plant extracts 101 , and bioactive molecules 102,103
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