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TME-targeting theranostic agent uses NIR tracking for tumor diagnosis and surgical resection and acts as chemotherapeutic showing enhanced efficiency and minimal toxicity
128 These insights support the integration of immune-restorative strategies, including checkpoint inhibitors, innate immune activators or adoptive cell therapies, into standard treatment paradigms
Significantly, metformin has been demonstrated to normalize pulsatile GnRH secretion by reducing circulating insulin levels
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