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Tryptophan oxidation products (kynurenine, oxindolylalanine) are specific impurities to monitor

So far, I have yet to come across a clear side effect but will keep an eye out for it

Background Autoimmune pancreatitis (AIP) is an increasingly recognised entity encompassing at least two types of pancreatitis.1 Type 1 AIP represents the most common manifestation of IgG4-related disease, a relapsing-remitting systemic fibro-inflammatory disorder characterised by increased production of IgG4 antibodies in affected tissues.1 Type 2 AIP is associated with inflammatory bowel diseases (namely Crohns disease and ulcerative colitis) and typically recurs less frequently than type 1 AIP.2 Although the pathogenesis of AIP is far from being solved, type 1 AIP likely involves the interplay between auto-reactive Footnotes Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content: ML, JM, EA and EDT

Smaller biotechs are also advancing promising candidates