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Originally for Diabetes: First approved in 2017 for type 2 diabetes, its powerful weight loss effects led to expanded use for obesity treatment
[8] Your healthcare provider may wish to perform blood tests to exclude other causes of cold intolerance, such as: Thyroid function tests (TSH, free T4) to rule out hypothyroidism Full blood count to check for anaemia Ferritin and iron studies , particularly if anaemia is suspected Vitamin B12 and folate levels , particularly if you have a history of metformin use (MHRA has issued a Drug Safety Update on metformin and B12 deficiency) [9] HbA1c to assess diabetes control It is important not to discontinue Ozempic without medical advice, as abrupt cessation may lead to deterioration in glycaemic control
The diabetes signal SELECT also recorded more cases of type 2 diabetes in the selenium group, though this particular difference was not statistically significant, meaning it could plausibly have been chance
Retatrutide is an investigational triple GIP/GLP-1/glucagon receptor agonist and currently provides the strongest clinical support for the glucagon paradox
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