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An enzyme-linked immunosorbent analysis showed that the higher cytokine secretion levels of IFN-, TNF- and interleukin 6 (IL-6, a critical modulator of innate immunity) in the AP20187 treated group compared to age-matched vehicle-treated controls could be observed
Overall, these described redox PTMs may explain why C
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Similarly, another study identified that pancreatic cancer-associated fibroblasts (CAFs) can secrete acetic acid into the stroma of pancreatic cancer, which is mediated by ATP citrate lyase (ACLY)
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