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33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)
In studies targeting adult neurogenic processes, however, longer chow treatment will result in a more heterogenous population of recombined cells at different stages of differentiation
Early Onset of Diminished Returns: If efficacy significantly decreases before the planned end of an on-cycle, researchers might consider shortening subsequent on-cycles or extending off-cycles
Cell Microbiol 4:6172
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