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The next step, which researchers are actively pursuing, is to confirm this in a direct disc herniation model
Pathophysiol 11 (1), 119
Regardless, the clinical safety in humans is still largely unknown
Furthermore, in human reviews 3 of muscle protein metabolism, activation of IGF-1/Akt/mTOR signaling directly correlated with higher protein synthesis rates and improved muscle density, particularly in response to resistance training and nutrient intake
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