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Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22

Bottom left : Elevated cytosolic Ca drives sustained muscle contraction and marked metabolic activation, increasing oxygen consumption, ATP utilization, and carbon dioxide production, thereby producing a hypermetabolic state

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