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doi:10.1136/openhrt-2017-000668 Uwitonze AM, Razzaque MS
While the liver was previously thought to be the main target of metformins glucose-lowering effects, recent evidence suggests that other parts of the body, such as the gastrointestinal tract, also play a role in its overall clinical advantages
However, the convenience of a single morning dose means most researchers prefer once-daily administration, and the clinical data supporting split dosing specifically for AOD 9604 is limited
On the rarer end of the spectrum, there are concerns like elevated blood pressure or prolonged erections that warrant attention
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