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The Institute for Clinical and Economic Review (ICER) in 2025 noted that price reductions and long-term benefits have improved GLP-1 cost-effectiveness relative to older assumptions ( [70] ), yet insurers still face high absolute spend

The combination of dehydration (from both the medication and alcohol), GI irritation, disrupted sleep, and potential blood sugar instability creates a hangover experience that is disproportionate to the amount consumed

One patient developed recurrent leukopenia at 1-4 months

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