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CrossRef Targeting LOXL1-expressing Hepatic Stellate Cell Inhibits Fibrogenesis and Sinusoid Angiogenesis via LOXL1/RUNX1/VEGFA Axis During Progression of Liver Fibrosis Xuzhen Yan, Qi Han, Yiwen Wang, Weiyu Li, Ning Zhang, Xu Fan, Wei Chen, Hong You, Aiting Yang Cellular and Molecular Gastroenterology and Hepatology .2026

Second, it has an additional 13 amino acids at its N-terminus, bringing the total to 83 amino acids compared to the 70 of standard IGF-1

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These agents have demonstrated robust efficacy in modulating metabolic dysfunctions central to MASLD progression, positioning them as a cornerstone in contemporary therapeutic strategies