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Compound 102 exhibited GPX4 activating effects in a concentration-dependent manner ( Figure 3 and Supplementary Figure S3 ), with both increased ratio of 5-HETE and LTB 4 and increased concentrations of 12-HETE and 15-HETE
The 2023 international evidence-based PCOS guideline positions lifestyle modification as foundational for all women, recommends metformin for metabolic features (especially at higher BMI), notes limited benefit for inositol, and importantly recognizes that anti-obesity medications, including GLP-1-based agents, can be considered for weight management in PCOS while emphasizing that evidence in this population remains limited and largely off-label
Blood 117 , 13111314 (2011)
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