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Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics

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However, it's important to note that the hydrochloride (HCl) molecule adds extra weight

NICE recommends GLP-1 receptor agonist medications for adults with type 2 diabetes who haven't achieved adequate glycaemic control with lifestyle changes and other treatments, or for obesity management when specific BMI and comorbidity criteria are met