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The rotarod test demonstrated significant recovery in mice treated with Au-PX-PLGA, with fall latency increasing from 66.00 37.18 s (untreated control group) to 291.17 8.66 s after 14 days, indicating a recovery in motor abilities
Akt/Nrf2 activation subsequently decreased oxidative stress leading to reduced lipid peroxidation and increased activities of the endogenous anti-oxidant defense enzymes, namely SOD, and GSH-Px
Nakano, M., Murayama, Y., Hu, L., Ikemoto, K., Uetake, T., & Sakatani, K
Theobromine, paraxanthine and the combined effects of methylxanthines
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