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Thus, N-acetyl-L-cysteine lowered blood pressure in hypertension (Tang et al., 1991), restored the content of GSH during myocardial infarction and heart failure in mice ( 2 S-synthesizing enzymes (pyridoxal-5-phosphate) restored eNOS coupling and endothelium-dependent vascular relaxation ( CSE knockout ( CSE/ ) mice, a low-cysteine diet resulted in glutathione and H 2 S deficiency, elevated plasma homocysteine levels, and developmental delay and death at 12 weeks of age ( 2 S in the regulation of the cardiovascular system in aging and prevention of the pathological processes

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