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Semaglutide can reduce fat in the liver, pancreas and visceral tissues, potentially enabling diabetes remission when weight loss exceeds 1015 percent
Broad gene expression studies show it acts as an "on/off switch" that inhibits inflammation while promoting cell-extracellular matrix interactions
Rotating injection sites between the abdomen, thigh, and upper arm can help minimise these localised effects
It was approved in 2018 as Ozempic at doses of 0.5 and 1.0 mg
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