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Improved potency and selectivity of Compound 11 toward PDE1B suggest that further substitution, such as difluoro-pyran-methyl-pyridine and methoxybenzyl at the C-6/C-8 and C-9 positions, can be employed to develop more potent PDE1B inhibitors
As a result, individuals experience prolonged feelings of fullness and satiety after eating
This is especially relevant for people using insulin or sulfonylureas, which can cause hypoglycemia (low blood sugar)
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