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doi:10.1098/rstb.2012.0212 4
Berberine inhibits the release of glutamate in nerve terminals from rat cerebral cortex
The mechanism of action includes several key effects: they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the brain to promote satiety and reduce food intake
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