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Abnormal activity of complex III was also identified in 29% of autistic brains, and 29% of them had defects in multiple complexes [81]

In addition, both riboflavin and PLP are essential determinants of the kynurenine pathway which influence glutamate receptors, hence, glutamate excitotoxicity potential, as shown in Section Riboflavin as a Determinant of the Kynurenine Pathway. Concerning PD, glutamate excitotoxicity contributes to dopaminergic neuronal loss (84)

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Twice-daily exenatide (Byetta) requires more specific timing: it should be administered within 60 minutes before the two main meals of the day (typically breakfast and dinner), at least 6 hours apart