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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

Metformin is widely available as a generic medication, making it an affordable option for people who need it

Those findings should not automatically be transferred to an independently supplied Reta product

[Abstract]2026 Jun 23:2026:7047803