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It was developed at the University of Arizona by Hruby and Hadley and contains two key modifications from native -MSH: a norleucine substitution at position 4 (replacing methionine) and a D-phenylalanine substitution at position 7 (replacing L-phenylalanine)

Room temperature storage should be avoided

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Researchers considering retatrutide should be aware of this potential effect and monitor for unusual skin sensations during dose escalation