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*Correspondence: Shinya Toyokuni, Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

DHFR is crucial for regenerating BH4 from its oxidized form, maintaining BH4s antioxidant capacity and continuous cellular protection from oxidative stress (Liang et al., 2023)

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