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reported that LS selectively upregulates lipocalin-type prostaglandin D synthase (L-PGDS), leading to elevated levels of prostaglandin D2 (PGD2) and its downstream anti-inflammatory metabolite, 15d-PGJ2, in the extracellular environment [230]
Penet, T
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At the same time, mast cells secrete cytokines that directly trigger the late-phase asthmatic response (TNF-a, IL-4, -5, -6) and recruit other inflammatory cells (IL-13 and GM-CSF)
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