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Immediate post-injection care is essential: after administering the injection, avoid rubbing or scratching the area, as this can worsen inflammation and prolong symptoms
Data availability Computer code for LSA, parameter estimation, numerical simulations, and GSA with PRCC was implemented in and run with the programming and computation software MATLAB (MathWorks Inc., Natick, MA, USA)
Validated mapping places the receptor in the arcuate and paraventricular nuclei of the hypothalamus, the area postrema, and the nucleus of the solitary tract in the brainstem, regions that govern hunger, satiety, and nausea
The CV region expresses a large amount of Cyp2e1 , so it undertakes the main drug metabolism function, which is also the main reason for the liver injury caused by carbon tetrachloride (CCL4) and APAP mainly around the CV region (Diaz Gmez et al., 2006
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