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[10] Valproate is restricted in the United Kingdom for both women and men under age 55 due to teratogenicity in pregnant women and fertility problems in men
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The evidence suggests that weight loss is the primary driver of the reproductive improvements seen with semaglutide, as substantial weight reduction is known to improve hormone balance, ovarian function and fertility in women with PMOS. Clare Thompson, MBBS, BSc, nMRCGP However, GLP-1 drugs may also have direct effects on reproductive health via mechanisms such as insulin signalling and ovarian function
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