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The decision to terminate the clinical development of Lotiglipron was based on the pharmacokinetic data from the clinical Phase 1 drug-drug interaction studies (NCT05671653 and NCT05788328), as well as the laboratory measurements of elevated transaminases in these Phase 1 studies and the ongoing Phase 2 study (NCT05579977)

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In the past, disability resulting from compromise of function of multiple cranial nerves as a result of a potential increase in the size of the tumor was considered an indication for early surgical intervention