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Intervention for leaky gut syndrome Patients with leaky gut syndrome are prone to systemic inflammation due to increased intestinal permeability

Abbreviations [Ca 2+ ] i : Intracellular Ca 2+ concentration ER: Endoplasmic reticulum GCG: Glucagon GCGR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GIPR: Glucose-dependent insulinotropic polypeptide receptor GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like peptide-1 receptor GSIS: Glucose-stimulated insulin secretion HFD: High-fat diet LFD: Normal chow diet KO: Knockout nt: Nucleotide PKC: Protein kinase C PLC: Phospholipase C TPPO: Triphenylphosphine oxide TRPM5: Transient receptor potential melastatin 5 WT: Wild-type References Finan B, Yang B, Ottaway N et al (2015) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

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The reciprocal substitution significantly impaired GLP-1R internalization, but not to the same extent as that of wild-type GIPR