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Do Rosalind Franklin and so many others ring a bell
This symptom is due to the action of the drug, which slows down digestion in the stomach, and will subside if administration is continued for a while
The peptide's resistance to dipeptidyl peptidase-IV (DPP-IV) proteolysis is achieved through substitution of -methyl-Phe at position 2, which blocks the cleavage of the Tyr1Ala2 bond that normally inactivates native incretins within minutes of secretion
2015;166(6):509-528.e1
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