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The move came in the wake of the FDAs move to remove semaglutide from its shortage list in February 2025
Example 9 Synthesis of semaglutide: 100mg of compound 4 obtained in example 5 with a purity of about 76.57% was added to an iced freshly prepared 1mL lysate (trifluoroacetic acid: thiobenzylbenzene: triisopropylsilane = 95
it is rapidly cleaved by carboxypeptidases, which suggests a short plasma residence time Pickart et al., 2018
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