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By creating an energy deficit and enhancing insulin sensitivity through weight loss, these agents may help reduce the factors that contribute to abdominal fat accumulation
This dual mechanism makes Tirzepatide one of the most effective non-surgical treatments available for sustainable weight reduction
Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]
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