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Moderate obesity, with a BMI of 30 to 35, can reduce life expectancy by three years

Reported incidences in those receiving a 12mg/weekly dose of retatrutide were [21]: Nausea (45% of participants) Vomiting (19%) Constipation (16%) Diarrhea (15%) Cardiac arrhythmia (11%) Fatigue (10%) Increased pancreatic enzyme (lipase) levels (8%) Injection site reactions (8%) Liver issues in 2 participants (3%) Pancreatitis in 1 participant (2%) Both tirzepatide and retatrutide share similar contraindications, including advice against their use during pregnancy and breastfeeding

Its not approved for weight loss, but for people with type 2 diabetes, its a good alternative

It has been widely studied in models of angiogenesis, gastrointestinal protection, tendon/ligament repair, and anti-inflammatory activity