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Because D-penetratin did not enhance the nose-to-brain delivery of exendin-4 and GLP-1, they suggested that D-penetratin/cargo complex that resists proteolysis, possibly remains in the cytoplasm compared to L-penetratin/cargo complex, and is released less to lamina propria located in the middle part of the olfactory bulb (Kamei et al., 2018)
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Most mild irritation resolves within one to two weeks with this approach
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