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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
TB500 is a synthetic heptapeptide fragment (Ac-LKKTETQ
LActyl L-Carnitine convient-elle tout le monde
Each format serves a distinct role depending on the study design and laboratory objectives
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